Antimicrobial and larvicidal activities of 2-hydroxypyrrolidine/piperidine derivatives

A novel series of various 2-hydroxypyrrolidine/piperidine derivatives were synthesized and their antibacterial activity against MTCC bacterial strains, anticancer activity and larvicidal effects were studied. Among the ten synthesized compounds, three were found to be antibacterial in nature. All the five test strains were highly sensitive to 1-(quinolin-3-yl) pyrrolidin-2-ol (P7), moderately sensitive to 1-(pyridin-4-yl) pyrrolidin-2-ol (P3) and less significantly to 1-(pyyrolidin-2-yl) piperidin-2-ol (p8). The maximum zone of inhibition was 28 ± 0.14 mm against Escherichia coli (MTCC 78) followed by 23± 0.14 mm against Klebsiella pneumoniae with 100 percent of relative inhibitory zone. The relative inhibitory zone of P3 against E.coli was 56% and 80 % against Klebsiella pneumoniae. Similarly 1-(quinolin-3-yl) pyrrolidin-2-ol (P7) showed a 60 % of larvicidal activity against Anaphelous sp and 53% against Culex sp.